Highly controlled dose of oral medication. Controlled and stable release of biopropene, including printing inkjet of polymetallic films as printing substrate and nanomaterials containing nanomaterials or containing such biopropene and preparation methods.
MORALES MONTECINOS JAVIER OCTAVIO,MONTENEGRO NICOLINI MIGUEL,CAMPANO HANTSCHERUK FELIPE AARON
申请号：
CL2016000112
公开号：
CL2016000112A1
申请日:
2016.01.15
申请国别(地区):
CL
年份:
2016
代理人:
摘要：
The invention relates to the pharmaceutical industry, particularly to the pharmaceutical industry related to drugs comprising biomacromolecules, or biopharmaceuticals. Even more particularly, the invention relates to a pharmaceutical form comprising biomacromolecules such as lymphokines, hormones, haematopoietic factors, growth factors, antibodies, enzymes, inhibitors, vaccines, and DNA or RNA derivatives. The invention provides a pharmaceutical form comprising biomacromolecules and a method for producing same based on inkjet printing using inks formed by nanosystems comprising the biomacromolecule(s), the drug or biopharmaceutical being administered orally. Even more particularly, the invention relates to a pharmaceutical form for oral administration of a highly controlled, stable controlled release dose of a biomacromolecule comprising: a) a polymer film as a printing substrate, formed by at least one pharmaceutically acceptable excipient； and b) an inkjet ink printed on the polymer film and comprising nanoparticles or nanoparticle suspensions comprising the biomacromolecule and at least one pharmaceutically acceptable excipient.una forma farmacéutica para administración bucal de dosis altamente controlada, con una liberación controlada y estable de una biomacromolécula que comprende: a) una película polimérica como sustrato de impresión constituida por al menos un excipiente farmacéuticamente aceptable y b) una tinta de inyección impresa sobre o en la superficie de la película polimérica que comprende nanopartículas o suspensiones de nanopartículas que comprenden dicha biomacromolécula y al menos un excipiente farmacéuticamente aceptable, donde dicha biomacromolécula se selecciona de una linfoquina, una hormona, factores hematopoyéticos, factores de crecimiento, anticuerpos, enzimas, inhibidores y vacunas. Un método para la fabricación de la forma farmacéutica.
