INSTITUTE FOR ANIMAL HEALTH;INTERVET INTERNATIONAL B.V.
发明人:
DAVID CAVANAGH,PAUL BRITTON,IAN TARPEY
申请号:
BRPI0407948
公开号:
BRPI0407948B1
申请日:
2004.03.03
申请国别(地区):
BR
年份:
2014
代理人:
摘要:
The present invention provides a vaccine for use in the protection of poultry against infectious bronchitis comprising an attenuated infectious bronchitis virus (IBV) and a pharmaceutical acceptable carrier or diluent, characterized in that the attenuated IBV comprises a heterologous spike gene. Such a vaccine is based on IBV strain Beaudette that is able to express a spike gone derived from a different IBV strain. The vaccines provided by the present invention also allow the administration via the in ovo route.