Provided are a modified Na-montmorillonite and a preparation method thereof, wherein the content of Na + in the modified sodium-montmorillonite, calculated as Na 2 O, is not less than 2.0%. The modified Na-montmorillonite has more reasonable microstructure, higher performance, and better quality. Also provided are a method for preparing a modified nanometered Na-montmorillonite from the modified Na-montmorillonite, and the modified nanometered Na-montmorillonite obtained by the method. Also provided are uses and a pharmaceutical composition of the modified Na-montmorillonite or modified nanometered Na-montmorillonite.