Syed M. Shah,Daniel Hassan,Christopher Diorio,Fred Hassan
申请号：
US15148665
公开号：
US09532952B2
申请日:
2016.05.06
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Controlled-release therapeutic compositions including melatonin combined with sedative and/or analgesic ingredients are described. The compositions have a solid core including melatonin in an acidified polymeric matrix. A sedative ingredient such as GABA receptor agonist may also be in the acidified polymeric matrix. The composition may include an expedited release portion providing a burst release of active ingredients and a sustained release portion providing a sustained release of active ingredients.
