Disclosed herein is a pharmaceutical composition comprises solid dispersion of BCS class II drug.TEL, in a novel solid carrier Gelucire 48/16, with pH modifiers. In accordance with the above objective, the present invention provides pharmaceutical compositions comprising solid dispersions of BCS class II drug dispersed in a Gelucires (polyethylene glycol glycerides composed of mono- and di esters of polyethylene glycol). One preferred BCS class II drug according to the invention is TEL.Linvention concerne une composition pharmaceutique comprenant du TEL médicamenteux de classe II en dispersion solide, dans un nouveau support solide Gelucire® 48/16, avec des modificateurs de pH.