National Research Council of Canada;University of Massachusetts Medical School
发明人:
Ian SCHOENHOFEN,Dennis M. WHITFIELD,Sanjay RAM
申请号：
US15693852
公开号：
US20170362269A1
申请日:
2017.09.01
申请国别(地区):
US
年份:
2017
代理人:
摘要：
N. gonorrhoeae has become resistant to almost every conventional antibiotic. Described herein is the use of CMP-nonulosonate analogues to counter gonococcal complement evasion. The nonulosonate sugar is incorporated into the lipooligosaccharide of the N. gonorrhoeae which in turn reduces the serum resistance of the bacteria. This provides a novel therapeutic strategy against the global threat of multi-drug resistant gonorrhea.
