Preparing ivabradine compounds (VI) comprises reacting 3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carbaldehyde (VII) with an amine (VIII) in the presence of a reducing agent. Preparing ivabradine compounds of formula (VI) comprises reacting 3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carbaldehyde of formula (VII) with an amine of formula (VIII) in the presence of a reducing agent. A : CH 2CH 2 or CH=CH. An independent claim is also included for (VII) in racemic or optically active form. [Image] [Image] ACTIVITY : Cardiant Antianginal Antiarrhythmic. MECHANISM OF ACTION : None given.Procédé de synthèse de livabradine de formule (I) :et de ses sels daddition à un acide pharmaceutiquement acceptable.
