The present disclosure relates to a compound represented by general formula (1), the compound being a small molecular kinase inhibitor having a macrocyclic molecular structure. The present disclosure also relates to a pharmaceutical composition comprising the compound and a therapeutic use thereof.本揭露涉及一種通式(I)所示化合物,該化合物是具有大環分子結構的小分子激酶抑制劑,還涉及包含該化合物的藥物組合物以及該化合物的治療用途,。