Patrício Manuel Vieira Araújo Soares Da Silva,Maria João Macedo Da Silva Bonifácio
申请号：
US14441043
公开号：
US09604970B2
申请日:
2013.11.14
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to compounds of formula I:for use in treating pulmonary arterial hypertension and associated conditions, where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group； R4 signifies hydrogen, alkyl, -alkylaryl or -alkylheteroaryl； X signifies CH2, oxygen atom or sulphur atom； n is 1, 2 or 3, with the proviso that when n is 1, X is not CH2； and the individual (R)- and (S)-enantiomers or mixtures of enantiomers and pharmaceutically acceptable salts thereof.
