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LIPOSOMAL FORMULATIONS
专利权人:
发明人:
申请号:
EP12776493.4
公开号:
EP2701734A2
申请日:
2012.04.25
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise liposomes formed from dimyristoylphosphatidylcholine (&ldquoDMPC&rdquo) either dimyristoylphosphatidylglycerol (&ldquoDMPG&rdquo) or dimyristoyltrimethylammonium propane (&ldquoDMTAP&rdquo) or both DMPC and DMTAP and at least one sterol and an antigenic polypeptide comprising a first polypeptide sequence, and a second polypeptide sequence heterologous the first polypeptide sequence which comprises a transmembrane sequence from a membrane protein, said transmembrane sequence having a number of residues sufficient to cross a lipid bilayer, at least nine contiguous residues of which are predicted to form an alpha helix having a hydrophobicity score of about 0.7 or greater.
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