SELECTIVE TNFR1 ANTAGONIST PEPTIDE SN10 AND APPLICATION THEREOF IN INFLAMMATORY BOWEL DISEASE

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专利权人:

LTD.;GUILIN EIGHT PLUS ONE PHARMACEUTICAL CO.

发明人:

Yiming LU,HAILONG JIANG,YINGYING BIAN,JIE WANG,AN LI,CHUAN ZHANG

申请号：

US16496640

公开号：

US20200277355A1

申请日:

2018.03.02

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The invention relates to the field of biomedicine, and in particular to a selective TNFR1 antagonist peptide Hydrostatin-SN10 derived from the snake venom of the ringworm, having the amino acid sequence as shown in SEQ ID NO: 2. The invention also provides a selective TNFR1 antagonist peptide PEG-SN10 based on mPEG2000 modification, which is modified by covalent attachment of the carboxyl group of mPEG2000 to the free amino group of the N-terminal aspartic acid of the Hydrostatin-SN10 peptide chain. At the same time, the present invention provides Hydrostatin-SN10 and PEG-SN10 for the treatment of inflammatory bowel disease.

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