Induced expression of brain-derived neurotrophic factor (BDNF) for the treatment of neuromuscular diseases, neurodegenerative diseases, autoimmune diseases, developmental diseases and / or metabolic diseases
In one embodiment, the present invention treats traumatic CNS injury, neurodegenerative disease, and / or autoimmune disease, and / or developmental disorder, and / or metabolic disease, increases BDNF, or moderates disease progression or symptoms In order to provide relief, a method of treatment is provided by administering DNP in a dosage range of 0.01 mg / kg body weight to less than 10 mg / kg body weight. DNP was administered daily to mice over various doses, after which a dose-dependent and non-linear increase in BDNF expression in the brain was shown.一実施形態では、本発明は、外傷性ＣＮＳ傷害、神経変性疾患、および／または自己免疫疾患、および／または発達障害、および／または代謝疾患を、ＢＤＮＦを増大させて疾患の進行を和らげるまたは症状の軽減をもたらすために、ＤＮＰを体重１ｋｇ当たり０．０１ｍｇ～体重１ｋｇ当たり１０ｍｇ未満の用量範囲で投与することによって処置する方法を提供する。ＤＮＰを様々な用量にわたってマウスに毎日投与し、その後、脳におけるＢＤＮＦ発現に用量依存性かつ非線形の発現の増大が示された。
