PURPOSE: A composition containing malabaricone C as an active ingredient is provided to suppress proliferation or migration of smooth muscle cells, and to prevent or treat vascular diseases such as hypertension, angina pectoris, cardiac infarction, ischemic heart diseases, heart failure, complication occurred after transluminal angioplasty, ischemic stroke, cerebral hemorrhage, and stroke.CONSTITUTION: A pharmaceutical composition for preventing or treating vascular diseases contains malabaricone C with a structure of chemical formula 1. The vascular diseases are selected from the group consisting of atherosclerosis, hypertension, angina pectoris, ischemic heart diseases, heart failure, complication occurred after transluminal angioplasty, ischemic stroke, cerebral hemorrhage, and stroke. The pharmaceutical composition induces expression of HO-1(heme oxygenase-1) in vascular smooth muscle cells. The pharmaceutical composition suppresses proliferation or migration of vascular smooth muscle cells.COPYRIGHT KIPO 2013본 발명은 말라바리콘 C(malabaricone C)를 유효성분으로 함유하는 평활근 세포의 증식 또는 이동 억제 효과가 있는 조성물에 관한 것으로, 상기 조성물은 동맥경화증, 고혈압, 협심증, 심근경색, 허혈성 심장질환, 심부전, 경혈관 동맥 성형술 후 발생하는 합병증, 뇌경색, 뇌출혈, 및, 뇌졸중 등과 같은 혈관 질환을 예방 및 치료할 수 있으며, 상기 질병들을 개선할 수 있는 다양한 치료제에도 유용하게 응용될 수 있다.
