Lorenza Fugazza,Francesco De Palo,Donato Barbato,Maurizio F. Mariani,Giovanni Tesoriere,Clementina Brambati
申请号：
US16393103
公开号：
US20200131224A1
申请日:
2019.04.24
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure relates to the synthesis of radionuclide complex solutions, in particular for their use in the commercial production of radioactive drug substances, for diagnostic and/or therapeutic purposes. In particular, the synthesis method comprises the following steps in the following order:a. providing a radionuclide precursor solution into a first vial,b. transferring the radionuclide precursor solution into a reactor,c. providing a reaction buffer solution into said first vial containing residual radionuclide precursor solution,d. transferring the buffer reaction solution and residual radionuclide precursor solution from said first vial into the reactor,e. transferring a peptide solution comprising the somatostatin receptor binding peptide linked to a chelating agent, into the reactor,f. reacting the somatostatin receptor binding peptide linked to a chelating agent with said radionuclide in the reactor to obtain the radionuclide complex,g. recovering said radionuclide complex.
