A full denture processing and shaping method and a material block thereof are disclosed. The full denture processing and shaping method comprises the follow steps of: providing a hard colored material block to be positioned to a processing device, a portion of the hard colored material block being shaped into a tooth-shaped structure； mounting the hard colored material block in an injection mold； injecting a soft plastic material with a different color into the injection mold, the soft plastic material being polymerized to form a gingival colored material block to constitute a multicolor structure； demoulding the injection mold to take out the material blocks for processing, the gingival colored material block being shaped into a denture base.
