David Arteta,Marcelo Ferrer,Laureano Simon,Antonio Martinez,Maria Uribarri
申请号：
US14386319
公开号：
US09398761B2
申请日:
2013.03.14
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A non-human transgenic animal having a polynucleotide encoding a PTN polypeptide, which polynucleotide is operably linked to a promoter, wherein said transgenic animal has greater than wild-type expression of the PTN polypeptide in at least one brain region, as well as related vectors, methods of producing transgenic animals, in vitro and in vivo screening methods for potential therapeutic agents, and methods for treating and diagnosing neuropsychiatric illnesses, particularly anxiety and depression, are disclosed.
