method for treating stroke in an individual, method for administering oxygen to an individual, method for treating a transient ischemic attack in an individual, method for treating a hypoxic brain injury in an individual, composition, pharmaceutical composition, use of a composition, kit and method for preparing a composition
ANA KRTOLICA,NATACHA LE MOAN,PHILBERTA LEUNG,STEPHEN P.L. CARY
申请号：
BR112018016829
公开号：
BR112018016829A2
申请日:
2017.02.16
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The invention provides h-nox proteins for oxygen delivery to hypoxic tissue after stroke. h-nox proteins leak into the stroke-associated hypoxic gloom and preferentially accumulate for sustained oxygen delivery to the hypoxic tissue to ameliorate the adverse effects of stroke-related hypoxia. in some embodiments, h-nox comprises pegylated h-nox and unpegylated h-nox.a invenção fornece proteínas h-nox para a entrega de oxigênio ao tecido hipóxico após acidente vascular cerebral. as proteínas h-nox extravasam para a penumbra hipóxica associada ao acidente vascular cerebral e acumulam-se preferencialmente para uma entrega sustentada de oxigênio ao tecido hipóxico para melhorar os efeitos adversos da hipoxia relacionada ao acidente vascular cerebral. em algumas concretizações, a h-nox compreende h-nox peguilada e h-nox não peguilada.
