The present invention provides antibodies and antigen-binding fragments of antibodies that bind to leptin receptor (LEPR), and methods of using the same. According to certain embodiments, the invention includes antibodies and antigen-binding fragments of antibodies that bind LEPR and activate LEPR signaling. In other embodiments, the invention includes antibodies and antigen-binding fragments of antibodies that bind to LEPR and enhance sensitization of LEPR to an antigen. In certain embodiments, the invention includes antibodies and antigen-binding fragments of antibodies that bind LEPR in the presence and absence of leptin. In certain embodiments, the invention includes antibodies and antigen-binding fragments of antibodies that induce signaling in cells expressing LEPR mutants that otherwise exhibit defective or impaired signaling in the presence of leptin. The antibodies and antigen-binding fragments of the present invention are useful for the treatment of lipodystrophies and other diseases and disorders associated with or caused by leptin deficiency or leptin resistance.本發明係提供與瘦素受體(LEPR)結合之抗體和抗體的抗原結合片段，以及彼等之使用方法。根據特定的實施例，本發明係包括結合LEPR和活化LEPR訊號傳遞之抗體和抗體的抗原結合片段。在其他的實施例中，本發明係包括與LEPR結合及增進LEPR對抗原之敏感性的抗體和抗體的抗原結合片段。在特定的實施例中，本發明係包括在有和無瘦素的存在下與LEPR結合之抗體和抗體的抗原結合片段。在特定的實施例中，本發明係包括在表現LEPR突變之細胞中引發訊傳遞之抗體和抗體的抗原結合片段，其中該突變係在瘦素的存在下具有缺陷和損傷的訊號傳遞。本發明之抗體和抗原結合片段可用於治療脂質失養和其他由瘦素缺乏或瘦素阻抗所造成或與其相關的疾病和病症。
