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СТАБИЛИЗИРОВАННЫЕ СОДЕРЖАЩИЕ АНТИТЕЛА ЖИДКИЕ КОМПОЗИЦИИ
专利权人:
ЧУГАИ СЕИЯКУ КАБУШИКИ КАИША (JP)
发明人:
ИГАВА Томоюки (JP),МОРИЯМА Чифуми (JP)
申请号:
RU2012135384/10
公开号:
RU2012135384A
申请日:
2011.01.20
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A stable composition comprising an antibody comprising a basic amino acid-basic amino acid or aspartate-glutamat.2. A composition according to claim 1, characterized in that it comprises histidine-aspartate-histidine buffer or glutamate buffer, wherein the basic amino acid is gistidin.3. A composition according to claim 1, characterized in that it comprises arginine or arginine-aspartate-glutamate, wherein the basic amino acid is arginin.4. A stable composition comprising an antibody comprising aspartate-histidine buffer or histidine buffer-glutamate, and aspartate-arginine or arginine-glutamat.5. A stable comprising an antibody composition comprising tris (hydroxymethyl) aminomethane-aspartate buffer or tris (hydroxymethyl) aminomethane-glutamate bufer.6. A stable comprising an antibody composition comprising tris (hydroxymethyl) aminomethane-aspartate buffer and tris (hydroxymethyl) aminomethane-glutamate bufer.7. A composition according to any one of claims 1-6, characterized in that essentially does not contain chloride ion and atsetata.8 ion. A composition according to claim 1, characterized in that it further comprises sahar.9. A composition according to claim 1, wherein the antibody is a humanized antibody or human antitelom.10. A composition according to claim 1, wherein the antibody has been modified to provide an isoelectric point (pI) of from 5 to 8.11. A composition according to claim 1, characterized in that the antibody concentration is 50 mg / ml or bolee.12. A composition according to claim 1, characterized in that the antibody concentration is from 50 to 250 mg / ml.13. A composition according to claim 1, characterized in that the liquid is kompozitsiey.14. A composition according to claim 13, characterized in that the viscosity of the liquid composition sost1. Устойчивая содержащая антитело композиция, включающая основную аминокислоту-аспартат или основную аминокислоту-глутамат.2. Композиция по п.1, отличающаяся тем, что включает гистидин-аспарт
来源网站:
中国工程科技知识中心
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