PROBLEM TO BE SOLVED: To provide glucagon analogs and stable glucagon analogs suitable for medical use, for example, to treat hypoglycemia in a liquid formulation.SOLUTION: Disclosed herein is a compound or pharmaceutically acceptable salt or solvate thereof, which comprises a specific amino acid sequence derived from an amino acid sequence of a formula (I): R1-Z-R2 in which R1 is hydrogen, C1-4 alkyl, acetyl, formyl, benzoyl or trifluoroacetyl； R2 is OH or NH2； and Z is an amino acid sequence deriving from the sequence of formula (Ia): His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Glu-Asn-Thr (Ia) with additional at least four amino acid substitutions or deletions only at specific positions.SELECTED DRAWING: NoneCOPYRIGHT: (C)2020,JPO&INPIT【課題】グルカゴン類似体、及び、例えば、低血糖の処置におけるそれらの液状製剤での医学的な使用に好適な安定したグルカゴン類似体の提供。【解決手段】式（Ｉ）：Ｒ1‐Ｚ‐Ｒ2（Ｉ）｛式中、Ｒ1が、水素、Ｃ1‐4アルキル、アセチル、ホルミル、ベンゾイル又はトリフルオロアセチルであり；Ｒ2が、ＯＨ又はＮＨ2であり；そしてＺが、式（Ｉａ）：Ｈｉｓ‐Ｓｅｒ‐Ｇｌｎ‐Ｇｌｙ‐Ｔｈｒ‐Ｐｈｅ‐Ｔｈｒ‐Ｓｅｒ‐Ａｓｐ‐Ｔｙｒ‐Ｓｅｒ‐Ｌｙｓ‐Ｔｙｒ‐Ｌｅｕ‐Ａｓｐ‐Ｓｅｒ‐Ａｒｇ‐Ａｒｇ‐Ａｌａ‐Ｇｌｎ‐Ａｓｐ‐Ｐｈｅ‐Ｖａｌ‐Ｇｌｎ‐Ｔｒｐ‐Ｌｅｕ‐Ｇｌｕ‐Ａｓｎ‐Ｔｈｒ（Ｉａ）の配列に由来し、且つ、特定の配列位置にのみ存在する少なくとも４個のアミノ酸置換又は欠失をさらに含む特定のアミノ酸配列を有する化合物、又は医薬的に許容され得るその塩若しくは溶媒和物。【選択図】なし
