Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.本文描述式I化合物、製備該等化合物之方法、含有該等化合物之醫藥組合物及藥物以及使用該等化合物治療或預防需要抑制硫酸乙醯肝素生物合成之疾病或病況的方法。