Public University Corporation Nagoya City University;Public University Corporation Yokohama City University;Pharma Foods International Co., Ltd.
发明人:
申请号：
EP16761721.6
公开号：
EP3266872A4
申请日:
2016.03.07
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Provided are anti-PAD4 antibodies having excellent properties and an excellent method for treatment of RA. Used are anti-PAD4 antibodies that specifically bind to an epitope containing positions 345, 347, and 348 of PAD4. These anti-PAD4 antibodies may inhibit the citrullination activity of PAD4. In addition, these anti-PAD4 antibodies may have a KD (M) of 9.0 × 10 -9 or less. Optionally, the anti-PAD4 antibody and a TNF± inhibitor are used in combination.
