HOOIJ, VAN, Onno,SCHALKEN, Jacobus Antonius,VIËTOR, Hendrik Engelbertus,PIET, Dennis Patrick,MAAS, Petrus Emmanuel Marie,TIJHUIS, Johann Heinrich,DEERENBERG, Sirik,SPRENKELS, Nanda Elisabeth,TANG, Siu
申请号：
EPEP2013/054449
公开号：
WO2013/131931A1
申请日:
2013.03.05
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
A compound having the structure according to formula III wherein: X is NH or S；R1 is H or (1C-4C)alkyl；R2 is (1C-4C)alkyl, phenyl or a monocyclic aromatic ring having one or more N-, O-or S-atoms in the ring, which alkyl, phenyl or aromatic ring is optionally substituted with one or more groups selected from (1C-4C)alkyl, (1C-4C)alkyloxy, halo(1C-4C)alkyl, halo(1C-4C)alkyloxy, phenyloxy, phenylthio, halogen, or nitro；R3 and R4 are each independently H, (1C-6C)alkyl, (2C-6C) alkenyl, (2C-6C)alkynyl, cyano, (3C-6C)cycloalkyl, phenyl, a monocyclic aromatic ring having one or more N-, O- or S-atoms in the ring, a monocyclic non-aromatic ring having one or more N-, O- or S-atoms in the ring, each optionally substituted with hydroxyl, (1C-4C)alkoxy, phenyl, cycloalkyl, piperidyl, piperazinyl, furyl, thienyl, pirazinyl, pyrrolyl, 2H-pyrrolyl, pyrazolyl, isoxazolyl, isothiazolyl, pyrrolidonyl, pyrrolinyl, imidazolinyl, imidazolyl, a monocyclic aromatic ring having one or more N-, O- or S- atoms in the ring, whereby each of these optional substituents is optionally further substituted with (1C-4C)alkyl, (1C-4C)alkyloxy, halo(1C-4C)alkyl, halo(1C-4C)alkyloxy, halogen, nitro or (1C-2C)dioxol forming a ring；or R3 and R4 form together pyrrolyl, imidazolyl, pyrazolyl, pyrrolidinyl, pyrrolinylimidazolidinyl, imidazolinyl, piperidyl, piperazinylmorpholinyl, each optionally substituted with (1C-6C)alkyl, phenyl(1C-4C)alkyl, phenylketo(1C-4C)alkyl； R5 is H, Cl, F, Br, Me, NO2, t-butyl, OCF3, OCH3, CF3； R6 is H, (1C-4C)alkyl, (1C-4C)alkyloxy, halo(1C-4C)alkyl, halo(1C-4C)alkyloxy, nitro or halogen；R7 is H,F, Cl, Br, Me, NO2, t-butyl, OCF3, OCH3, CF3； or pharmaceutically acceptable addition salts thereof for use in treatments of carcinoma, in particular to delay, prevent or reverse metastasis in prostate cancer.Composé ayant la structure selon la formule III dans laquelle: X est NH ou S； R1 représente H ou un alkyle en C1-4； R2 représente un alkyle en C1-4, un phényle ou un noyau aroma
