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Dispersion and formation method for hydrogels
专利权人:
Nissan Chemical Industries; Ltd.
发明人:
IMOTO, Takayuki,IWAMA, Takehisa
申请号:
ES13810250
公开号:
ES2660484T3
申请日:
2013.06.25
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Dispersion characterized by comprising: at least one of the lipid peptide type compounds of formula (1) and formula (2) and pharmaceutically acceptable salts of the compounds; and at least one alcohol selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 2-ethyl-1,3-hexanediol and ethylene glycol monoalkyl ether or a mixed solution of at least one alcohol and water: in which R1 is a C9-23 aliphatic group; R2 is a hydrogen atom or a C1-4 alkyl group optionally having a C1-2 branching chain; R3 is a group - (CH2) n-X; n is a number from 1 to 4; and X is an amino group, a guanidino group, a -CONH2 group or a 5-membered ring that optionally has 1 to 3 nitrogen atom (s), a 6-membered ring that optionally has 1 to 3 atom (s) ) of nitrogen or a condensed heterocyclic ring consisting of a 5-membered ring and a 6-membered ring that optionally have 1 to 3 nitrogen atom (s), wherein R4 is a C9-23 aliphatic group; R5 to R7 are each independently a hydrogen atom, a C1-4 alkyl group optionally having a C1-2 branching chain or a group - (CH2) n-X; n is a number from 1 to 4; X is an amino group, a guanidino group, a -CONH2 group or a 5-membered ring that optionally has 1 to 3 nitrogen atom (s), a 6-membered ring that optionally has 1 to 3 atom (s) of nitrogen or a condensed heterocyclic ring consisting of a 5-membered ring and a 6-membered ring that optionally have 1 to 3 nitrogen atom (s).Dispersión caracterizada por comprender: al menos uno de los compuestos de tipo péptido lipídico de fórmula (1) y fórmula (2) y sales farmacéuticamente aceptables de los compuestos; y al menos un alcohol seleccionado del grupo que consiste en 1,2-pentanodiol, 1,2-hexanodiol, 1,2- octanodiol, 2-etil-1,3-hexanodiol y monoalquiléter de etilenglicol o una disolución mixta del al menos un alcohol y agua: en la que R1 es un grupo alifático C9-23; R2 es un átomo de hidrógeno o un grupo alquilo C1-4 que tiene opcionalmente una cadena de ramificación C1-2; R3 es un grupo -
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中国工程科技知识中心
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