GRAY, PETER C.,SHANI, GIDI,KELBER, JONATHAN A.,VALE, WYLIE
申请号：
CA2743057
公开号：
CA2743057C
申请日:
2009.11.09
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention provides methods compositions and methods for treating ahyperproliferative disease comprisingdisrupting Cripto/GRP78 complex formation in a hyperproliferative cell. Incertain embodiments, an antibody and/or siRNAmay be used to inhibit Cripto/GRP78 binding, optionally coupled with othercancer therapies. Also provided are methods foridentifying therapeutic compounds which can selectively inhibit Cripto/GRP78binding.
