HOVEYDA, HAMID R.,VEZINA, MARTIN,FOURNIER, ERIC,GAGNON, RENE,BHERER, PATRICK
申请号：
MX2012003912
公开号：
MX2012003912A
申请日:
2010.09.29
申请国别(地区):
MX
年份:
2012
代理人:
摘要：
The present invention provides novel salts and solvates of macrocyclic compounds that bind to and/or are functional agonists of the ghrelin (growth hormone secretagogue) receptor. The invention also relates to polymorphs of these salts and solvates, pharmaceutical compositions containing these salts or solvates, and methods of using the pharmaceutical compositions. These pharmaceutical compositions are useful as therapeutics for a range of disease indications, in particular, for treatment and prevention of gastrointestinal disorders including, but not limited to, postoperative ileus, gastroparesis, including diabetic and postsurgical gastroparesis, opioid bowel dysfunction, chronic intestinal pseudo-obstruction, short bowel syndrome, functional gastrointestinal disorders and gastrointestinal dysmotility, such as that occurring in conjunction with other disease states, in critical care situations or as a result of treatment with pharmaceutical agents. Additionally, the pharmaceutical compositions have application to the treatment and prevention of metabolic and/or endocrine disorders, cardiovascular disorders, central nervous system disorders, bone disorders, inflammatory disorders, hyperproliferative disorders, disorders characterized by apoptosis and genetic disorders.La presente invención proporciona sales y solvatos novedosos de compuestos macrocíclicos que se unen a y/o son agonistas funcionales del receptor de grelina (secretagogo de la hormona del crecimiento) la invención también se relaciona con polimorfos de estas sales y solvatos, composiciones farmacéuticas que contienen estas sales o solvatos y métodos de uso de las composiciones farmacéuticas estas composiciones farmacéuticas son útiles como terapéuticos para una serie de tratamientos de enfermedades, en particular, para el tratamiento y prevención de trastornos gastrointestinales incluyendo, sin restricción, íleo postoperatorio, gastroparesis, incluyendo gastroparesis diabética y postquirúrgica, disfun
