A method of performing a transperineal biopsy procedure including sliding a displacement member of a biopsy guide relative to a guide member of the biopsy guide such that the displacement member is proximate the perineal access site of the patient. The guide member may be secured to the ultrasound probe, and the guide member may include a pair of guide rails each having a planar top surface. The displacement member may include a platform having a planar bottom surface and at least one needle receiving port for guiding a needle, wherein the planar bottom surface of the platform opposes the planar top surfaces of the pair of guide rails during the sliding of the displacement member relative to the guide member. The method may further include inserting a needle into the perineal access site of the patient.
