WU, Yun,KOPECKO, Dennis J.,SIM, B. Kim Lee,HOFFMAN, Stephen L.
申请号：
EP16821934
公开号：
EP3319629A4
申请日:
2016.07.06
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Disclosed is the attenuated Salmonella typhi vaccine Ty21a utilized as a vector for Shigella and/or enterotoxogenic E. coli genes stably integrated in the Ty21a chromosome. These genes include a heterologous Shigella sonnei O-antigen biosynthetic gene region that comprises the wzz gene and expresses Shigella sonnei form 1 O-antigen, as well as a heterologous acid resistance biosynthetic gene system comprising a YbaS gene, which enables increased stability of the Ty21a vector at pH 2.5 relative to Ty21a without the integrated acid resistance biosynthetic gene system.
