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צורת מינון המכילה מלח אי–אורגני העמידה בפני שבירה
专利权人:
GRUNENTHAL GMBH
发明人:
申请号:
IL22462113
公开号:
IL224621A
申请日:
2013.02.07
申请国别(地区):
IL
年份:
2017
代理人:
摘要:
The invention relates to a pharmaceutical dosage form exhibiting a breaking strength of at least 500 N, said dosage form containing a pharmacologically active ingredient (A); an inorganic salt (B); and a polyalkylene oxide (C) having a weight average molecular weight of at least 200,000 g/mol, wherein the content of the polyalkylene oxide (C) is at least 20 wt.-%, based on the total weight of the dosage form; wherein the pharmacologically active ingredient (A) is present in a controlled-release matrix comprising the inorganic salt (B) and the polyalkylene oxide (C) and wherein, under in vitro conditions, the release profile of the pharmacologically active ingredient (A) from said matrix comprises at least a time interval during which the release follows zero order kinetics.
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中国工程科技知识中心
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