KESHAVJEE, SHAFIQUE,LIU, MINGYAO,CYPEL, MARCELO,SAGE, ANDREW
申请号：
CA3070522
公开号：
CA3070522A1
申请日:
2018.07.30
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Methods and kits for screening, diagnosing, detecting or predicting a patientoutcome/risk variable for a lung transplantrecipient after transplant or an EVLP outcome by measuring biomarker levels ofone or more biomarkers selected from IL-6, IL-8,sTNFR1 and sTREM-1 in EVLP perfusate are described. The methods involve forexample, i. obtaining one or more test EVLP perfusatesamples of a donor lung； ii. determining in one or more test EVLP perfusatesample of a donor lung, a polypeptide level of one or morebiomarkers selected from IL-8, IL-6, sTNFR1 and sTREM-1； and iii. a) comparingthe polypeptide level of the one or more biomarkersin the perfusate sample with a control or cut-off level, wherein thedifferential level is indicative of outcome/risk of after transplantor of an EVLP outcome； or b) using the polypeptide level of one or several ofthe one or more biomarkers in combination, as part ofan algebraic calculation of outcome/risk.
