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Human anti-CD27 antibodies, methods and uses
专利权人:
Janssen Biotech; Inc.
发明人:
Chen, John,Fransson, Johan,Fursov, Natalie,Hamel, Damon,Malia, Thomas,Obmolova, Galina,Ort, Tatiana,Rycyzyn, Michael,Scully, Michael,Sweet, Raymond,Teplyakov, Alexey,Wheeler, John,Almagro, Juan Carlos
申请号:
AU2013232087
公开号:
AU2013232087B2
申请日:
2013.03.14
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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