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Risperidone or Paliperidone Implant Formulation
专利权人:
Laboratorios Farmacéuticos Rovi; S.A.
发明人:
Ibon GUTIERRO ADURIZ,Guillermo FRANCO RODRIGUEZ
申请号:
US16368258
公开号:
US20190254960A1
申请日:
2019.03.28
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The present invention is directed to an injectable intramuscular depot composition suitable for forming an in situ solid implant in a body, comprising a drug which is risperidone and/or paliperidone or any pharmaceutically acceptable salt thereof in any combination, a biocompatible copolymer based on lactic and glycolic acid having a monomer ratio of lactic to glycolic acid of about 50:50 and a DMSO solvent, wherein the composition releases the drug with an immediate onset of action and continuously for at least 4 weeks and wherein the composition has a pharmacokinetic profile in vivo that makes it suitable to be administered each 4 weeks or even longer periods.
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