The present disclosure relates to an image processing device, an image processing method, and a surgical system that enable detection of a region including a specific living body site in an intraoperative image on the basis of a frequency of a motion vector of a living body in the intraoperative image.A motion detection unit detects the motion vector of the living body in the intraoperative image using the intraoperative images at different times. The analysis unit obtains the frequency of the motion vector detected by the motion detection unit. A frequency map generation unit detects the region including the specific living body site in the intraoperative image on the basis of the frequency obtained by the analysis unit. The present disclosure is applicable to, for example, a CCU and the like of an endoscopic surgical system.