The present invention provides transdermal formulation, wherein, the adhesive layer of drug containing is formed on supporting mass, aforementioned adhesion layer at least contains thermoplastic elastomer (TPE) and high-grade aliphatic ester, and the content of tackifier is not more than 10 weight %, and the preparation is excellent in terms of drug solubility and release property and to the adhesiveness of skin and to the low irritant of skin.
