Carboxylate compounds derived from phenyl ketone and its salts； a Pharmaceutical composition that comprises； and its use for the Prevention or treatment of a Blood Disorder, inflammatory disease, kidney disease or organ dysfunction associated with fibrosis.
Phenylketone carboxylate compounds of Formula I, wherein n=2-6； R=C(0)； -OC(O)- or -CH(OH)-； A is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when B is Ft B is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when A is Ft or A and B form a 5-7 membered cycloalkyl substituted with COOFt W=0, S or NFt Y=0,S,NH or CH2； m=0-2； p=1-7； have been prepared. These compounds and their pharmaceutically acceptable salts have beneficial therapeutic effects to prevent or treat a condition related to (l) blood disorders, (ii) inflammation related diseases, (iii) renal disorders and/or renal disorders complications, or (iv) fibrosis-related organ dysfunction.<；p>；La presente tnvenció；n se retiere a un compuesto de Fó；rmula (I) o ；una sal farmacé；uticamente aceptable de esta, una composició；n farmacé；utica que lo comprende, y su uso ；en el tratamiento de un trastorno hematoló；gico, enfermedad ；inflamatoria, un trastorno renal o una disfunció；n de ó；rganos relacionada ；con la fibrosis.<；/p>；
