NOVEL SUBSTITUTED BENZYL DERIVATIVES INCLUDING ACTVATED VINYL GROUP AND PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF NEUROLOGICAL DISEASES THROUGH BOTH ACTIVATING OF NRF2 AND INHIBITING OF PRODUCING NITRIC OXIDE
울산대학교 산학협력단;UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION;한국과학기술연구원;KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人:
KIM, DONG JIN,김동진,PARK, KI DUK,박기덕,PARK, WOONG SEO,박웅서,KIM, YOUNG SOO,김영수,KIM, JIN WOO,김진우,WOO, SEO YEON,우서연,HWANG, ON YOU,황온유,KIM, YUN KYUNG,김윤경,BYEON, SEONG RIM,변성림,KANG, YONG KOO,강용구
申请号：
KR1020120045727
公开号：
KR1020130122420A
申请日:
2012.04.30
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
The present invention relates to a benzyl derivative compound containing an activated vinyl group, pharmaceutically acceptable salt of the same, and a pharmaceutical composition which contains the benzyl derivative compound as an active component. The benzyl derivative compound has nitric oxide production inhibiting and NF-E2-related factor-2 (Nrf2) activating effects for preventing and treating brain neurological diseases, especially Parkinson`s disease, dementia of the Alzheimers type, Huntington disease, Lou Gehrig`s disease, epilepsy, depression, insomnia, uneasiness, and degenerative cerebral nerve diseases caused by the functional disorder and death of nerve cells.본 발명은 활성화된 비닐기를 포함하는 벤질 유도체 및 이의 약제학적으로 허용가능한 염, 그리고 이들 화합물이 유효성분으로 함유된 약학조성물에 관한 것으로, 산화질소 생성 억제 및 NF-E2-related factor-2 (Nrf2) 활성 작용하여 신경세포 기능 장애 및 사멸로 인하여 야기되는 뇌신경 질환, 특히 파킨슨병, 알츠하이머 치매, 헌팅턴병, 루게릭병, 간질, 우울증, 불면증, 불안증 및 퇴행성 뇌신경 질환의 치료 및 예방제로 효과를 보인다.
