Weight loss can be promoted by folding a portion of the gastric fundus of a human subjects stomach in proximity to the distal portion of the subjects left gastric artery (including its smaller branches), and clipping the tissue so that it stays in the folded state. The clips cause endovascular flow reduction or interruption to the fundus. The reduced or interrupted blood flow decreases the production of the hormone ghrelin, which reduces the subjects appetite, thereby promoting weight loss. A similar procedure may also be implemented in portions of the subjects stomach that are in proximity to other arteries.
