AFAR, DANIEL E.,HUBERT, RENE S.,LEONG, KAHAN,RAITANO, ARTHUR B.,JAKOBOVITS, AYA,SAFFRAN, DOUGLAS C.
申请号：
AU2008246270
公开号：
AU2008246270B2
申请日:
2008.11.20
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Described is a novel gene and its encoded secreted tumor antigen, termed BPC-1, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express BPC- 1, particularly including prostate cancer and bladder cancer. In human normal tissues, BPC-I is only expressed in certain tissues of the brain. However, BPC-l is expressed at high levels in prostate cancer cells and is also expressed in bladder cancer cells. The structure of BPC- I includes a signal sequence and a CUB domain. BPC-1 protein is secreted. Preliminary experimental evidence suggests that BPC- I is directly involved in oncogenesis or maintenance of the transformed phenotype of cancer cells expressing BPC-1. BPC-I also appears to bind specifically to a cellular protein expressed in prostate cancer cells and other cells.
