Provided are an Unmanned Aerial Vehicle (UAV) operating method and device. The method includes that: mapping information of an operation object to be operated is acquired, the mapping information including a safe height, geographic position information and a spray radius, of the operation object; a flight height of the UAV is adjusted to the safe height, and the UAV flies, according to the safe height, to a position corresponding to the geographic position information; and at the position corresponding to the geographic position information, a spiral spraying operation is performed on the operation object based on the spray radius (103).