The invention provides ophthalmic formulations containing well-defined substituted gamma lactams. The formulations described herein are useful in treating a variety of ocular diseases related to ocular hypertension, such as for example, glaucoma.本發明提供一種包含明確定義的經取代γ內醯胺之眼用調配物。文中所述之調配物係用於治療與高眼壓相關之各種眼病,諸如(例如)青光眼。