Modificirani oligonukleotidi za inhibicijo telomeraze

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专利权人:

GERON CORPORATION

发明人:

GRYAZNOV Sergei,PONGRACZ Krisztina

申请号：

SI200432487

公开号：

SI3342425T1

申请日:

2004.09.09

申请国别(地区):

SI

年份:

2020

代理人:

摘要：

Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.

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