1. Plot Fc antibodies, where the plot Fc contains a substitution of one or more amino acids selected from positions 239, 282, 289, 297, 312, 324, 330, 335, 337, 339, 356, 359, 361, 383, 384, 398 , 400, 440, 422 and 442.2. Section Fc according to claim 1, where the section Fc contains one or more of the following pairs of substitutions: a) 289 and 440； b) 330 and 440； c) 339 and 440； d) 359 and 440； e) 289 and 359； e ) 330 and 359； g) 339 and 359； h) 289 and 339； i) 330 and 339； j) 289 and 330； il) 339 and 442.3. Plot Fc according to claim 1, where the plot Fc contains one or more of the following substitution groups: a) 289, 339 and 442； b) 289, 330 and 339； c) 330, 339 and 442； ig) 289, 330 and 442.4. The Fc region of claim 1, wherein the Fc region is selected from the isotype IgG1, IgG2, IgG3 or IgG4.5. The Fc region of claim 1, wherein the substitution comprises amino acids with an amino acid selected from cysteine, lysine, tyrosine, histidine, selenocysteine and selenomethionine. Section Fc according to claim 5, in which the substitution contains cysteine. The Fc region of claim 6, wherein the cysteine contains a thiol group. The Fc region of claim 7, wherein the thiol group is capable of chemical conjugation. The Fc region of claim 8, wherein the Fc region is conjugated to one or more of a cytotoxic agent, chemotherapeutic agent, toxin, radionuclide, DNA, RNA, siRNA, micro-RNA, peptide nucleic acid, a non-naturally occurring nucleic acid, peptide, enzyme, fluorescent label and biotin. 10. An antibody or antigen binding fragment thereof comprising the Fc region of claim 1. The antibody or antigen binding fragment of claim 10, wherein said antibody is a monoclonal, chimeric, humanized, fully human, bispecific, multispecific antibody or antibody-like molecule. The antibody or antigen binding fragment of claim 10, wherein the antibody further comprises the substitution of one or more amino�1. Участок Fc антитела, где участок Fc содержит замещение одной или более ам
