A platform and methods of use, for providing active, pre-determined, fullycontrolled, precise delivery of nano- or micro-particles in biological tissue.The platformcomprises the following modules: (A) one or more nano- or micro-particlescomprising embeddedlogic and various MEM components； (B) a delivery and retraction module,configuredto deliver and retract the particles； (C) an external signal generator； (D) animagingmodule, configured to monitor said particles； and (E) an integration moduleconfigured toreceive inputs from other modules and provide output control commands to othermodules.The modules are configured to interact/communicate with each other and areinternally controlled,externally controlled or both.
