A closed-wound drainage device is provided in the following two forms: (1) an irregularly-shaped foam drug-containing coverage material, a drainage tube, a canister and a pressure source and (2) a flat foam drug-containing coverage material, a drainage tube, a canister and a pressure source. The function of which is to cover the wound and to drain, promote cell growth and accelerate wound healing when the pressure source operates. Its operation method is as follows: put the irregularly-shaped or flat foam drug-containing coverage material on the wound so that the adhesive layer is attached to normal skin, then connect the drainage tube with the canister and the pressure source. When the pressure source activates, the irregularly-shaped or flat foam drug-containing coverage material is attached to the surface of the wound to accelerate recovery of the wound.