BEALS JOHN MICHAEL,Beals John Michael,CUTLER GORDON BUTLER,Cutler Gordon Butler,DOYLE BRANDON,Doyle Brandon,HANSEN RYAN JOHN,Hansen Ryan John,LI SHUN,Li Shun,SHIRANI SHAHRIAR,Shirani Shahriar,ZHANG LI
申请号：
SI200930944
公开号：
SI2476430T1
申请日:
2009.06.09
申请国别(地区):
SI
年份:
2014
代理人:
摘要：
The present invention relates to the field of diabetes. More particularly, the invention relates to PEGylated insulin lispro compounds that are PEGylated with high molecular weight poly(ethylene glycol), are highly soluble at physiological pH, have an extended duration of action, and characterized by pharmacokinetic, pharmacodynamic, and/or activity peak-trough ratios of less than 2. The invention also relates to methods of providing such molecules, to pharmaceutical compositions containing them, and to their therapeutic uses.
