Kamesh R. Sirigireddy,Paulraj K. Lawrence,Russell F. Bey,Randy R. Simonson
申请号：
US13385303
公开号：
US20120225091A1
申请日:
2012.02.13
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention is a live vaccine from a culture of cells of Haemophilus parasuis exhibiting attenuated pathogenicity and capable of triggering a protective immune response when administered to pigs. The cell culture was modified from a pathogenic parent strain by MNNG mutagenesis and was selected by complete dependence on streptomycin for growth. Several SNPs have been identified as associated with specific proteins that are associated with virulence as seen in the literature in H. parasuis or related bacterial species.
