PROBLEM TO BE SOLVED: To provide compositions, which are effective for prophylaxis and treatment of diseases or disorders, such as cell-proliferation, angiogenesis, or apoptosis mediated diseases, and therapeutic methods using the compositions.SOLUTION: The therapeutic methods include bringing an effective amount of a cool-genic compound into contact with cancerous cells. The cool-genic compound is represented by the following compound, etc.COPYRIGHT: (C)2013,JPO&INPIT【課題】細胞増殖、血管新生、又はアポトーシス媒介疾患のような疾患又は障害の予防と治療に効果的な組成物およびそれを用いた治療方法の提供。【解決手段】有効量の冷感誘起化合物に癌性細胞を接触させることを含んでなる癌の治療方法。当該冷感誘起化合物は以下化合物等に代表される。【選択図】なし