Nicholas P. Restifo,Lydie Cassard,Zhiya Yu,Steven A. Rosenberg
申请号：
US12522321
公开号：
US08216565B2
申请日:
2008.01.11
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having antigenic specificity for amino acids 154-162 of gp100 (SEQ ID NO: 1), as well as related polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding fragments thereof, conjugates, and pharmaceutical compositions, are further provided. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host comprising the use of the inventive materials described herein.
