[Purpose] The disclosure provides a package structure of an agent for skin external application, which is unfolded upon the opening of the package structure and very easily separated from the stack structure, and a method of fabricating the package structure for the agent for skin external application.[Constitution] An agent 2 for skin external application is interposed between a film-type base material 3 and a film-type cover material 4, the resultant product is folded by employing the cover material 4 as a folding surface, and the four-layer overlap material including the base material 3-the cover material 4-the cover material 4-the base material 3 provided at a peripheral portion of the folded structure is closed through thermal bonding.
