The Board of Trustees of the Leland Stanford Junior University
发明人:
Bianxiao Cui,Yi Cui,Ziliang Lin,Chong Xie
申请号：
US15640142
公开号：
US20170296806A1
申请日:
2017.06.30
申请国别(地区):
US
年份:
2017
代理人:
摘要：
This disclosure provide a nanopillar electrode device, comprising a substrate patterned with a plurality of metal pads. The device may further comprise a plurality of nanopillars electrode arrays, wherein each nanopillar electrode array is attached to the substrate above a metal pad and electrically connected to the pad. The device may further comprise and a chamber surrounding the nanopillar electrodes, which can be used for culturing cells of interest for recording action potentials. The nanopillar electrode device may be configured to apply a voltage through the nanopillar electrodes from a voltage source. Nanopillar electroporation may be used to increase the permeability of cell membranes to allow intracellular recording. Also provided are methods of device fabrication, and methods of use.
